Quantitative Optical Coherence Tomography Angiography Biomarkers for Alport Syndrome

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Ana Cunha (Author) FMUP; Teixeira, D (Author) Other; Cabral, D (Author) Other; Estrela-Silva, S (Author) FMUP; Falcao-Reis, F (Author) Other; Ângela Carneiro (Author) FMUP

Journal

Title: Ophthalmologica

Vol. 245

Pages: 41-48

ISSN: 0030-3755

Publisher: Karger

Indexing

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Other information

Authenticus ID: P-00W-851

DOI: 10.1159/000519242

Abstract (EN): Purpose: The aim of this study was to evaluate microvascular abnormalities of patients with Alport syndrome (AS) using optical coherence tomography angiography (OCT-A) quantitative biomarkers. Methods: This was cross sectional, prospective evaluation of consecutive patients with AS and healthy subjects. AS diagnosis was performed by the genetic test. All participants underwent a retinal vasculature evaluation by spectral-domain optical coherence tomography (SD-OCT) and OCT-A of the macula. Quantitative analysis included whole vascular density, foveal avascular zone area, fractal dimension (FD), and lacunarity (LAC). Results: Ninety-four eyes were included in this study, 45 eyes from patients with AS and 49 eyes from healthy subjects. The pathogenic mutation in the COL4A5 gene on the chromosome X was found in 14 patients; the pathogenic autosomal recessive mutations in the COL4A3 gene were found in 9 patients. Quantitative evaluation demonstrated a significant difference between AS and healthy subjects on LAC of the superficial capillary plexus and deep capillary plexus (DCP) (p < 0.001 and p < 0.001, respectively) and on FD in the DCP (p < 0.001). Conclusion: The DCP Alport patients have a higher vessel nonuniformity than DCP of healthy subjects. We hypothesize that endothelial cell lesion in the setting of low resistance at the DCP circuit could lead to long-term structural disorganization. (C) 2021 S. Karger AG, Basel

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8