Chemical composition and anti-cancer properties of Juniperus oxycedrus L. essential oils on estrogen receptor-positive breast cancer cells

• Type: Article in International Scientific Journal
• Date: 2019

Authors

El Abid, H (Author) Other; Amaral, C (Author) Other; Cunha, SC (Author) Other; Augusto, TV (Author) Other; Fernandes, JO (Author) FFUP; Georgina Correia da Silva (Author) FFUP; Teixeira, NA (Author) FFUP; Moumni, M (Author) Other

Journal

Title: Journal of Functional Foods

Vol. 59

Pages: 261-271

ISSN: 1756-4646

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-00Q-NP2

DOI: 10.1016/j.jff.2019.05.042

Abstract (EN): Fruits from Juniperus oxycedrus L. (Cupressaceae) are generally used in gastronomy and in folk medicine to treat cancer. In this study, the anti-cancer efficacy of essential oils (EOs) of fruits and leaves from Moroccan J. oxycedrus L., was investigated in ER+ breast cancer cells. Both EOs presented anti-proliferative effects but, curiously, only fruits EOs impaired cancer cell growth and induced apoptosis. To characterize the chemical composition of these EOs, a suitable HS-SPME/GC MS method was developed. Among the SPME fibers used, the PDMS and PA were the most effective for characterization of volatile compounds. Moreover, these EOs are rich in alpha-pinene and beta-myrcene, which also presented anti-cancer properties. For the first time, the anti-cancer properties of EOs and of new potential bioactive molecules of J. oxycedrus L. in ER+ breast cancer cells were highlighted, suggesting their potential adjuvant therapeutic role in breast cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11