The Impact of Chronic Pelvic lschemia on LUTS and Urinary Levels of Neuroinflammatory, Inflammatory, and Oxidative Stress Markers in Elderly Men: A Case-control Study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Antunes Lopes, T (Autor) FMUP; Vasconcelos, A (Autor) Outra; Costa, D (Autor) Outra; Charrua A. (Autor) FMUP; Neves, J (Autor) FMUP; João Silva (Autor) FMUP; Francisco Cruz (Autor) FMUP; Carlos Silva (Autor) FMUP

Revista

Título: Urology

Vol. 123

Páginas: 230-234

ISSN: 0090-4295

Editora: Elsevier

Indexação

ISI Web of Knowledge - 15 Citações

Scopus - 15 Citações

Outras Informações

ID Authenticus: P-00P-WC3

DOI: 10.1016/j.urology.2018.09.004

Abstract (EN): OBJECTIVE To investigate lower urinary tract symptoms (LUTS) and urinary levels of neuroinflammatory, inflammatory, and oxidative stress markers in elderly men with chronic pelvic ischemia (CPI) caused by significant aortoiliac disease. MATERIALS AND METHODS Thirteen men aged over 60 years, with aorta, unilateral or bilateral common/internal iliac artery occlusion documented by computed tomography angiography or angiography, were enrolled from the vascular surgery department. Twelve sex- and age-matched controls without significant aortoiliac disease were used for comparison. Exclusion criteria included neurogenic bladder dysfunction, bladder or prostate cancer, prostatic surgery, pelvic radiotherapy, or chronic treatment for LUTS. Participants underwent urological examination, including assessment of International Prostate Symptom Score (IPSS), uroflowmetry, postvoid residual (PVR), and prostate volume. Urine samples were collected, and levels of neuroinflammatory (nerve growth factor, NGF), inflammatory (cytokines), and oxidative stress markers (8-hydroxy-2'-deoxyguanosine) were determined by enzyme-linked immunosorbent assay. RESULTS Groups were similar for age, PVR, prostate volume, and most cardiovascular risk factors. IPSS was higher in patients with CPI (11 +/- 3 vs 8 +/- 2, P = .02), with a significant mean difference between groups of three points. Urinary NGF was significantly higher in men with CPI (3.7 +/- 0.8 vs 2.9 +/- 0.7, P = .02), but no differences were found in inflammatory and oxidative biomarkers among groups. CONCLUSION Severe CPI in elderly men is associated with a significant increase in LUTS and bladder neurogenic inflammation, as suggested by the increase of NGF release in urine, sensitizing bladder afferents. These findings confirm the relevance of ischemia in bladder function and appear to validate animal models of bilateral iliac artery occlusion. (C) 2018 Elsevier Inc.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5