Systems for transport and intracellular delivery

Code:

Q4083

Acronym:

Q4083

Level:

400

Keywords
Classification	Keyword
OFICIAL	Chemistry

Instance: 2023/2024 - 1S

Active?	Yes
Responsible unit:	Department of Chemistry and Biochemistry
Course/CS Responsible:	Master in Applications in Biotechnology and Synthetic Biology

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
M:ABBS	19	The study plan from 2019/20.	1	-	6	42	162
M:CTN	1	Official Study Plan since 2020_M:CTN	1	-	6	42	162
			2

Teaching language

Portuguese

Objectives

The present course aims to provide students with a comprehensive view of the of existing intracellular delivery systems, their properties and how they can be modulated according to the desired biomedical and biotechnological applications. 

Learning outcomes and competences

At the end of the course, the students should have acquired the following competences:

(i) recognize the central role of intracellular delivery as a developing area in biotechnology, biomedicine and pharmaceutical sciences with applications in various types of therapeutic agents (drugs, oligonucleotides, peptides and other bioproducts)

(ii) know the fundamental physical and chemical properties of the various types of systems for efficient intracellular delivery, including viral particles, cell penetrating peptides, liposomes, polymer particles and various types of nanoparticles;

(iii) recognize and understand the main routes of design of peptide delivery systems;

(iv) understand the fundamental characteristics and properties of delivery systems of biological origin.

Working method

Presencial

Program

1. Biotechnological drug delivery systems

Different systems for vehiculation and delivery of drugs and genes (non-viral systems) will be addressed: characterization and properties; advantages disadvantages; Protection, bioavailability, encapsulation/delivery efficiency; smart delivery.

1.1. Liposomes (simple and modified), lipid nanoparticles, lipid/protein microcapsules; applications. Nano and microgels; Lipoplexes and polyplexes. Applications.

1.2. Design and synthesis of peptide-based delivery systems.

1.3. Polymers in the delivery of bioactive systems

 

Mandatory literature

Ranade, V. V.; Cannon, J. B. ; Drug Delivery Systems, CRC Press – Taylor and Francis Group, LLC, 2011
M. Çagdas, A. D. Sezer and S. Bucak, ; , Liposomes as potential drug carrier systems for drug delivery, open access peer-reviewed chapter, DOI: 10.5772/58459, 2017
Wang, B.; Hu, L.; Siahaan, T. J. ; Drug Delivery: Principles and Applications, 2nd Edition, 2016
Sheikhpoura, M.; Barani, L.; Kasaeian, A. ; Biomimetics in drug delivery systems: A critical review., Journal of Controlled Release, 253, 97-109. , 2017
Yoo, J.-W.; Irvine, D. J.; Discher, D. E.; Mitragotri, S. ; Bio-inspired, bioengineered and biomimetic drug delivery carriers, Nature Reviews, 10, 521-535. DOI: 10.1038/nrd3499, 2011

Teaching methods and learning activities

Tutorial classes 

The classes will have an expository and interactive character according to the above-mentioned program. In addition, the students will make oral presentations and discussions based on topics or papers that that they were provided with beforehand.
Depending of the Covid siuation evolution, and following the Direction instructions on the subject, the classes of this unit will be either partially or totaly online.

The evaluation is carried out based oncontinuous assessment of the student’s performance in tutorial classes, based on paper presentations in group (NTP-A) and a writen individual monography, on subject to be provided (NTP-B) 

Evaluation Type

Distributed evaluation without final exam

Assessment Components

designation	Weight (%)
Apresentação/discussão de um trabalho científico	50,00
Trabalho escrito	50,00
Total:	100,00

Amount of time allocated to each course unit

designation	Time (hours)
Apresentação/discussão de um trabalho científico	20,00
Frequência das aulas	60,00
Trabalho escrito	20,00
Total:	100,00

Eligibility for exams

To be present in at least 2/3 of the total number of planned classes, and to present t least one of the twomplanned oral presentations.

Calculation formula of final grade

Final classification (NF): NF = 0.50 x NTP-A + 0.50 x NTP-B

where NTP-A consists of an orel presentation and subsequent discussion of a paper (group work) and NTP-B is a monography (individual)

Special assessment (TE, DA, ...)

Students with special evaluation conditions (working students) that do not comply with the minimum requirements to enable successfull result will do an idividual assessment. The same aplied to those that have their missing classes duly justified, and oficially accepted.

Observations

Juri

Maria Fernanda Martins Borges
Margarida Maria Henriques Mesquita Bastos