Synthesis of Drugs

Code:

Q4024

Acronym:

Q4024

Level:

400

Keywords
Classification	Keyword
OFICIAL	Chemistry

Instance: 2015/2016 - 2S

Active?	Yes
Responsible unit:	Department of Chemistry and Biochemistry
Course/CS Responsible:	Master in Chemistry

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
M:BQ	5	Plano de Estudos do MBIOQ_2013-2014	1	-	6	56	162
M:Q	3	Official study plan until 2022/2023	1	-	6	56	162

Teaching language

Portuguese

Objectives

The general objectives:
* Provide knowledge of use to other chairs in chemistry and related courses and focused on work / professional
* Understanding of organic chemistry as a science experimentalist and its importance and influence in other areas (eg pharmaceuticals)
* Being able to understand texts related to organic chemistry and develop the ability to critically analyze the information received
* Develop an interest in observing phenomena related to organic chemistry occurring in the real world and everyday life, especially events of nature biological, pharmaceutical (industrial) and medicinal
The specific objectives regarding the following matters:
- Structure of organic compounds and functional groups
- Basic Nomenclature in organic chemistry
- Stereochemistry and its biological significance
- Synthesis and reactivity of organic compounds
- Organic compounds of biological interest
- Organic chemistry in the world of drug design

Learning outcomes and competences

Once this course has been planned to introduce and develop fundamental concepts of organic synthesis of the main families of drugs (organic molecules associated with its pharmacological activities).  In addition to explain these reasons, appear to design synthetic strategies and the stereochemistry associated with such strategies of organic synthesis.
It also demonstrates the application of data and concepts presented in solving chemical problems and the role that organic chemistry plays in the development of new drugs.
In laboratory classes, the basic techniques of isolation, purification and identification of organic compounds are seized by performing mini projects connected with current research taking place in our labs DQB.

Working method

Presencial

Program

Lectures:
1.  HALOGENATION REACTIONS
2. SUBSTITUTION AND ELIMINATION REACTIONS
3. AMINES
4. ALCOHOLS
5. ALKENES
6. AROMATIC SYSTEMS
7. CARBONYL GROUP
8.CARBOXYLIC DERIVATIVES
9. PROTECTING GROUPS
10. CARBAMATES
11: GUANIDINES
12. CYCLOPROPANES AND CYCLOBUTANES
13. BENZOIC ACID DERIVATIVES
14. ACETIC ACID DERIVATIVES
15. ARILSULFONAMIDES AND SULPHONYLUREAS
16. ETHYLAMINE DERIVATIVES. DIARYLPROPYLAMINAS.
17. ETHYLAMINE DERIVATIVES..
18. ETHYLAMINE DERIVATIVES.. OXIETHYLAMINAS
19. PYRIDINE and PYRIMIDINE DERIVATIVES
20. PENTACYCLIC PI-EXCESS SYSTEMS.
21. QUINOLINE DERIVATIVES
22. ISOQUINOLINE DERIVATIVES
23. QUINAZOLINES AND  QUINAZOLONES
24. BENZIMIDAZOLE DERIVATIVES

PRACTICAL SECTION (mini-projects):
- glucuronides
- derivatives of primaquine
- neuroprotective agents
- chiral alcohos
- prolinomimetic tripeptides
- surfactants derived from amino acids
- nucleoside analogues

Mandatory literature

Vollhardt, K. P. e Shore, N. E., W. H. Freeman and Company.; ORGANIC CHEMISTRY
D. C. Eaton, Mc Graw-Hill Book Company, 1989; " Laboratory Investigations in Organic Chemistry"
Clayden, Greeves, Warren and Wothers; Oxford (www.oup.com); ORGANIC CHEMISTRY

Complementary Bibliography

Schore, N. E, Ed,. W. H. Freeman and Company. ; “Organic Chemistry - Study Guide and Solutions Manual"
C. Afonso, D. Simão, L. Ferreira, M. E. Serra, M.M. Raposo, C. Afonso, D. Simão, L. Ferreira, M. E. Serra, M.M. Raposo, IST Press, 2011; "100 experiências de química orgânica"
Mc Murry, J., Brooks/Cole Publishing Company.; ORGANIC CHEMISTRY
Mc Murry, S., Ed., Brooks/Cole Publishing Company. ; “Organic Chemistry-Study Guide and Solutions Manual”

Comments from the literature

During the semester will be provided material support classes and other bibliographic sources.

Teaching methods and learning activities

Type of evaluation:  Continuous distributed
Terms of frequency:  in accordance with the Statutes.
Evaluation:
1) Realization of three frequencies (A, B, C) by way of exercises over a period of 2 hours. These exercises can be performed with bibliographic.
Rating = average grade of the two best exercises performed by the student.
2) Carrying out home exercises.
Rating = average grade of exercises performed.
3) Development of a (F) placed by the teacher about the synthesis of a drug.
Component Lectures (NT):
(NT) = 0.3 x [1 +2 +3 +4 +5 + ... n) / n] + 0.4 [(A + B or C) / 2] + 0.3 × F
(1,2,3,4, 5, ..... n): home exercises.
(A + B or C) = the two highest grades of three frequencies ("exercises")
F = Work of synthesis of a drug made by the lecturer
Component of practical classes (NP):
4) Laboratory practice jobs involves carrying out mini-projects in the  Organic Chemistry section of the Department. (NP)
FINAL STANDINGS (NF) = 0.7 5x NT + 0.25 x NP

keywords

Physical sciences
Physical sciences > Chemistry > Applied chemistry > Pharmaceutical chemistry

Evaluation Type

Distributed evaluation without final exam

Assessment Components

designation	Weight (%)
Exame	20,00
Participação presencial	10,00
Teste	22,50
Trabalho escrito	22,50
Trabalho laboratorial	25,00
Total:	100,00

Eligibility for exams

Regulation of FCUP

Calculation formula of final grade

FINAL STANDINGS (NF) = 0.7 5x NT + 0.25 x NP

Examinations or Special Assignments

Regulation of FCUP

Special assessment (TE, DA, ...)

Regulation of FCUP

Classification improvement

Regulation of FCUP

Observations

Type classes: Theoretical (2 h / week);
Type classes: theoretical-practical (exercices) (1 h/ week)
Type classes: Laboratory Practice (1 h / week) with flexible hours.