Bioinformatics

Code:

Q4025

Acronym:

Q4025

Level:

400

Keywords
Classification	Keyword
OFICIAL	Chemistry

Instance: 2013/2014 - 2S

Active?	Yes
Responsible unit:	Department of Chemistry and Biochemistry
Course/CS Responsible:	Master in Biochemistry

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
M:BQ	14	Plano de Estudos do MBIOQ_2013-2014	1	-	6	56	162
M:Q	19	Official study plan until 2022/2023	1	-	6	56	162

Teaching language

Portuguese

Objectives

The main objective of the lectures is to provide a broad overview of Bioinformatics.
In the practical classes the students will develop small research projects.

Learning outcomes and competences

Expertise in the use of bioinformatic tools and softwares. Capacity to identify bioactive compounds by virtual screening. Expertise in macromolecule modelling. Capacity for choosing the most adequate bioinformatic tool for each biochemical problem.

 

Working method

Presencial

Program

Lectures.

1. Bioinformatics vs. computational biochemistry.
2. Quantum Mechanics
3. Quantum Mechanics vs Classical Mechanics
4. Protein structure and modelling
4.1. Docking protein-ligand
4.2. Virtual screening
4.3. Docking protein-protein
4.4. Homology modelling
5. Computational mutagenesis


Practical classes.

The students will develop a small drug design research project.

Mandatory literature

Ana Cecília A. Roque; Ligand-Macromolecular Interactions in Drug Discovery, Ana Cecília A. Roque, 2009. ISBN: 978-1-60761-243-8
Leach Andrew R.; Molecular modelling. ISBN: 0-582-38210-6

Teaching methods and learning activities

Lectures, often realised with workshops.
Practical computational classes, with one student per computer.
e-learning at: http://www.compbiochem.org/democritus/

Evaluation Type

Distributed evaluation with final exam

Assessment Components

designation	Weight (%)
Exame	50,00
Participação presencial	20,00
Trabalho escrito	30,00
Total:	100,00

Amount of time allocated to each course unit

designation	Time (hours)
Elaboração de relatório/dissertação/tese	24,00
Estudo autónomo	70,00
Frequência das aulas	56,00
Total:	150,00

Eligibility for exams

Attendance of 75% of the practical classes and presentation of final report on work done.
Final exam.

Calculation formula of final grade

The final mark corresponds to the average of the mark obtained in the exam and the mark given in the practical classes and corresponding report made by the student.

The mark obtained in the exam mostly reflects the result of the final exam, which is scheduled by the Conselho Pedagógico of the Faculty. The mark might be slightly adjusted by the personal evaluation that the lecturer does during the lectures. The weight of the exam for the final mark is 50%.

The practical mark is the result of the final report the student makes (30% for the total mark) and the personal evaluation the teacher performs during the practical classes (20% for the total mark).

Examinations or Special Assignments

Detailed report on work done in the practical classes.

Classification improvement

Repeating the final exam.