Magnetic liposomes based on nickel ferrite nanoparticles for biomedical applications

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Rodrigues, ARO (Author) Other; Gomes, IT (Author) Other; Almeida, BG (Author) Other; araujo, j. p. (Author) FCUP; Castanheira, EMS (Author) Other; Coutinho, PJG (Author) Other

Journal

Title: Physical Chemistry Chemical Physics

Vol. 17

Pages: 18011-18021

ISSN: 1463-9076

Publisher: Royal Society of Chemistry

Indexing

ISI Web of Knowledge - 40 Citations

Scopus - 45 Citations

Other information

Authenticus ID: P-00G-CJP

DOI: 10.1039/c5cp01894c

Abstract (EN): Nickel ferrite nanoparticles with superparamagnetic behavior at room temperature were synthesized using a coprecipitation method. These magnetic nanoparticles were either covered with a lipid bilayer, forming dry magnetic liposomes (DMLs), or entrapped in liposomes, originating aqueous magnetoliposomes (AMLs). A new and promising method for the synthesis of DMLs is described. The presence of the lipid bilayer in DMLs was confirmed by FRET (Forster Resonance Energy Transfer) measurements between the fluorescent-labeled lipids NBD-C-12-HPC (NBD acting as a donor) included in the second lipid layer and rhodamine B-DOPE (acceptor) in the first lipid layer. An average donor-acceptor distance of 3 nm was estimated. Assays of the non-specific interactions of magnetoliposomes with biological membranes (modeled using giant unilamellar vesicles, GUVs) were performed. Membrane fusion between both aqueous and dry magnetoliposomes and GUVs was confirmed by FRET, which is an important result regarding applications of these systems both as hyperthermia agents and antitumor drug nanocarriers.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11