On mining protein unfolding simulation data with inductive logic programming

• Tipo: Artigo em Livro de Atas de Conferência Internacional
• Data: 2008

Autores

Rui Camacho (Autor) FEUP; Alexessander Alves (Autor) Outra; Cândida G. Silva (Autor) Outra; Rui M. M. Brito (Autor) Outra

Ata de Conferência Internacional

Título: 2nd International Workshop on Practical Applications of Computational Biology & Bioinformatics (IWPACBB 2008)

Páginas: 175-179

2nd International Workshop on Practical Applications of Computational Biology & Bioinformatics (IWPACBB 2008)

Salamanca, Espanha, Outubro 2008

Indexação

ISI Web of Science

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia electrotécnica, electrónica e informática

CORDIS: Ciências Tecnológicas > Engenharia > Engenharia do conhecimento

Outras Informações

DOI: 10.1007/978-3-540-85861-4_21

Abstract (EN): The detailed study of folding and unfolding events in proteins is becoming central to develop rational therapeutic strategies against maladies such as Alzheimer and Parkinson disease. A promising approach to study the unfolding processes of proteins is through computer simulations. However, these computer simulations generate huge amounts of data that require computational methods for their analysis. In this paper we report on the use of Inductive Logic Programming (ILP) techniques to analyse the trajectories of protein unfolding simulations. The paper describes ongoing work on one of several problems of interest in the protein unfolding setting. The problem we address here is that of explaining what makes secondary structure elements to break down during the unfolding process. We tackle such problem collecting examples of contexts where secondary structures break and (automatically) constructing rules that may be used to suggest the explanations.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5