Lipid Nanoparticles Functionalized with Antibodies for Anticancer Drug Therapy

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2023

Autores

Marques, AC (Autor) FFUP; Paulo Costa (Autor) FFUP; Velho, S (Autor) Outra; Maria Helena Amaral (Autor) FFUP

Revista

Título: Pharmaceutics

Vol. 15

Página Final: 216

ISSN: 1999-4923

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus

Outras Informações

ID Authenticus: P-00X-PJV

DOI: 10.3390/pharmaceutics15010216

Abstract (EN): Nanotechnology takes the lead in providing new therapeutic options for cancer patients. In the last decades, lipid-based nanoparticles-solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), liposomes, and lipid-polymer hybrid nanoparticles-have received particular interest in anticancer drug delivery to solid tumors. To improve selectivity for target cells and, thus, therapeutic efficacy, lipid nanoparticles have been functionalized with antibodies that bind to receptors overexpressed in angiogenic endothelial cells or cancer cells. Most papers dealing with the preclinical results of antibody-conjugated nanoparticles claim low systemic toxicity and effective tumor inhibition, which have not been successfully translated into clinical use yet. This review aims to summarize the current state-of-the-art in anticancer drug delivery using antibody-functionalized lipid-based nanoparticles. It includes an update on promising candidates that entered clinical trials and some explanations for low translation success.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 22