Lipid nanocarriers for the loading of polyphenols ¿ A comprehensive review

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Pimentel-Moral, S (Autor) Outra; Teixeira, M (Autor) Outra; Fernandes, A (Autor) Outra; Arráez-Román, D (Autor) Outra; Martínez-Férez, A (Autor) Outra; Segura-Carretero, A (Autor) Outra; Souto, E (Autor) Outra

Revista

Título: Advances in Colloid and Interface Science

Vol. 260

Páginas: 85-94

ISSN: 0001-8686

Editora: Elsevier

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 42 Citações

Outras Informações

ID Authenticus: P-00Y-1EY

DOI: 10.1016/j.cis.2018.08.007

Abstract (EN): Polyphenols are secondary metabolites found in all vascular plants and constitute a large group of at least 10,000 unique compounds. Particular attention is currently being paid to polyphenols attributed to their beneficial effects in the protection and prevention of several diseases. While their use in food, pharmaceutical and cosmetic industries is largely documented, several environmental conditions (e.g. light, temperature or oxygen) may affect the physicochemical stability of polyphenols, compromising their bioactivity in vivo. To overcome these limitations, the loading of polyphenols into nanoparticles has been proposed aiming at both increasing their bioavailability and reducing eventual side effects. Lipid nanoparticles offer several advantages, namely their biodegradability and low toxicity, with the additional capacity to modify the release profile of loaded drugs. This paper is a review of the recent advances of lipid nanocarriers commonly used for the encapsulation of poly phenols, highlighting their added value to increase bioavailability and bioactivity of this group of compounds as well as their application in several diseases.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10