Encapsulation of Active Pharmaceutical Ingredients in Lipid Micro/Nanoparticles for Oral Administration by Spray-Cooling

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Favaro Trindade, CS (Author) Other; Junior, FDE (Author) Other; Okuro, PK (Author) Other; Dias Ferreira, J (Author) Other; Cano, A (Author) Other; Severino, P (Author) Other; Zielinska, A (Author) Other; Souto, EB (Author) Other

Journal

Title: Pharmaceutics

Vol. 9

Final page: 1186

ISSN: 1999-4923

Publisher: MDPI

Indexing

ISI Web of Knowledge - 8 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00V-739

DOI: 10.3390/pharmaceutics13081186

Abstract (EN): Nanoencapsulation via spray cooling (also known as spray chilling and spray congealing) has been used with the aim to improve the functionality, solubility, and protection of drugs; as well as to reduce hygroscopicity; to modify taste and odor to enable oral administration; and many times to achieve a controlled release profile. It is a relatively simple technology, it does not require the use of low-cost solvents (mostly associated to toxicological risk), and it can be applied for lipid raw materials as excipients of oral pharmaceutical formulations. The objective of this work was to revise and discuss the advances of spray cooling technology, with a greater emphasis on the development of lipid micro/nanoparticles to the load of active pharmaceutical ingredients for oral administration.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14