Dietary patterns derived from principal component analysis (PCA) and risk of colorectal cancer: a systematic review and meta-analysis

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Garcia Larsen, V (Author) Other; Morton, V (Author) Other; Norat, T (Author) Other; Moreira, André (Author) FMUP; Potts, JF (Author) Other; Reeves, T (Author) Other; Bakolis, I (Author) Other

Journal

Title: European Journal of Clinical Nutrition

Vol. 73

Pages: 366-386

ISSN: 0954-3007

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 44 Citations

Other information

Authenticus ID: P-00Q-BRM

DOI: 10.1038/s41430-018-0234-7

Abstract (EN): Background and aim Colorectal cancer (CRC) is highly prevalent worldwide, with dietary habits being a major risk factor. We systematically reviewed and meta-analysed the observational evidence on the association between CRC and dietary patterns (DP) derived from principal component analysis. Design PRISMA guidelines were followed. Web of Science, Medline/PubMed, EMBASE, and The Cochrane Library were searched to identify all eligible papers published up to the 31st July 2017. Any pre-defined cancer of the colon was included, namely colon-rectal cancer (CRC), colon cancer (CC), rectal cancer (RC), or proximal and distal CC, if available. Western (WDP) and prudent (PDP) dietary patterns were compared as a proxy to estimate "unhealthy" (Rich in meat and processed foods) and "healthy" diets (containing fruits or vegetables), respectively. Meta-analyses were carried out using random effects model to calculate overall risk estimates. Relative risks (RR) and 95% confidence intervals were estimated comparing the highest versus the lowest categories of dietary patterns for any of the forms of colon cancer studied. Results 28 studies were meta-analysed. A WDP was associated with increased risk of CRC (RR 1.25; 95% CI 1.11, 1.40), and of CC (RR 1.30; 95% CI 1.11, 1.52). A PDP was negatively associated with CRC (RR 0.81; 95% CI 0.73, 0.91). Sensitivity analyses showed that individuals from North-and South-American countries had a significantly higher risk of CRC than those from other continents. Conclusion A PDP might reduce the risk of CRC. Conversely, a WDP is associated with a higher risk of disease.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 21