Mineralization of regenerated cellulose hydrogels induced by human bone marrow stromal cells

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Granja, PL (Author) Other; De Jeso, B (Author) Other; Bareille, R (Author) Other; Rouais, F (Author) Other; Baquey, C (Author) Other; Barbosa, MA (Author) FEUP

Journal

Title: European Cells and Materials

Vol. 10

Pages: 31-39

ISSN: 1473-2262

Publisher: AO Research Institute Davos

Indexing

ISI Web of Knowledge

Scopus - 15 Citations

Other information

Authenticus ID: P-007-EEA

Abstract (EN): The proliferation of cultured human bone marrow stromal cells (HBMSC) on regenerated cellulose hydrogels was assessed. Regenerated cellulose hydrogels showed good rates of HBMSC proliferation, the cells exhibiting a flattened morphology, and after 22 days in culture, the cells had homogeneously colonized the surface of the materials. Moreover, since the early days in culture, between the surface of the materials and attached cells a continuous granulated hydroxyapatite layer was formed. It has been previously demonstrated in vitro, but without cells, that these materials did not mineralize. Hence, it seems that HBMSC promoted the mineralization of the surface.

Language: English

Type (Professor's evaluation): Scientific