Venous thromboembolism and prostate cancer: what about genetic markers?

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2021

Autores

Abreu, SC (Autor) Outra; Tavares, V (Autor) Outra; Carneiro, F (Autor) Outra; Rui Medeiros (Autor) ICBAS

Revista

Título: Pharmacogenomics

Vol. 22

Páginas: 365-373

ISSN: 1462-2416

Editora: ASHLEY PUBLICATIONS LTD

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00T-P6J

DOI: 10.2217/pgs-2020-0094

Abstract (EN): Aim & methods: To review the existing literature concerning the relationship between venous thromboembolism (VTE) and prostate cancer (PC) and explore the putative biological and clinical implications of VTE genetic markers on PC patients by screening the PubMed database. Results: Considering the roles of VTE genome-wide association studies-identified genetic determinants in disease development in the general population, these variants might also underlie the susceptibility for PC-related VTE. Therefore, they could help to identify those with a positive benefit-to-harm ratio for thromboprophylaxis approaches during cancer therapy management, thereby improving patient's prognosis. Conclusion: Future studies are mandatory to explore the relationship between VTE and PC and dissect the predictive value of VTE genome-wide association studies-identified genetic determinants in PC patients, given their clinical implications.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10