Photostabilization strategies of photosensitive drugs

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2018

Autores

Coelho, L (Autor) Outra; Almeida, IF (Autor) FFUP; Sousa Lobo, JMS (Autor) Outra; Paulo Silva (Autor) FFUP

Revista

Título: International Journal of Pharmaceutics

Vol. 541

Páginas: 19-25

ISSN: 0378-5173

Editora: Elsevier

Indexação

ISI Web of Knowledge - 36 Citações

Scopus - 42 Citações

Outras Informações

ID Authenticus: P-00N-MWP

DOI: 10.1016/j.ijpharm.2018.02.012

Abstract (EN): Purpose: Several active compounds are sensitive to light, especially to the ultraviolet radiation (UV-R) leading to their degradation or modification, with lost or decrease of their biological activity. The aim of this study was to perform a systematic review regarding photostabilization strategies used on health products and perform a critical appraisal of their effectiveness. Results: The bibliographic search identified 2261 results and merely 40 studies met the selection criteria. Of these, 85% referred to encapsulation strategies, 10% to antioxidants and 5% to the use of solar filters. Cyclodextrins (CD's) were the most used encapsulation systems (32.5%) followed by liposomes and lipid nanoparticles (each 17.5%), microparticles (15%) and polymeric nanoparticles (10%). The most effective were found to be liposomes and lipid nanoparticles. However, the different methodological conditions used limit the true relevance of this finding. Conclusions: A gold standard strategy suitable for all compounds cannot be proposed. Instead, case-by-case evaluation, supported on the photodegradation mechanism is recommended. Systematic studies that compare different photostabilization strategies undertaken with the same irradiation conditions are also needed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7