Biocompatible cdots dual role: Nanophotosensitizers for hypoxic photodynamic therapy and scavenging nanozyme biosensing

• Type: Article in International Scientific Journal
• Date: 2024-08

Authors

Susana A. F. Neves (Author) FEUP; Helena M.R. Gonçalves (Author) Other; Sabela Rodriguez (Author) Other; Rui F.P. Pereira (Author) Other; Rui Vilarinho (Author) FCUP; Tânia Moniz (Author) ICBAS; Maria Rangel (Author) ICBAS; J. Agostinho Moreira (Author) FCUP; Paula Martins-Lopes (Author) Other; Filomena Adega (Author) Other; Frank Davis (Author) Other; Séamus P.J. Higson (Author) Other; Marita A. Cardoso (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: Biosensors and Bioelectronics: X

Vol. 19

ISSN: 2590-1370

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-010-GM3

DOI: 10.1016/j.biosx.2024.100499

Abstract (EN): Within this study we report a non-toxic nanomaterial suitable for Photodynamic Therapy (PDT) under hypoxic conditions. PDT relies on the production of reactive oxygen and nitrogen species that can lead to cancer cells death. Currently, PDT is limited by: the development of efficient photosensitizers that can produce these radicals in situ; and the oxygen level requirement. The produced Carbon Dots (Cdots) successfully destroy human melanoma cancer cells upon 5 min irradiation using 450 nm wavelength due to the in situ production of NO¿. As such, this nanophotosensitizer is applicable regardless of the cells molecular oxygen levels. Additionally, this nanomaterial acts as a scavenging nanozyme biosensor allowing to follow-up, in situ, the released NO¿ concentration, thereby offering a tight control over the NO¿ concentration in real-time and, its maintenance within the therapeutic window. Hence, this work offers a novel theranostic and NO¿ scavenging nanozyme biosensing nanoplatform that allows high control for hypoxic-PDT cancer application even in low doses and with 5 min irradiation. © 2024 The Authors

Language: English

Type (Professor's evaluation): Scientific