Prognostic Effect of the Dose of Loop Diuretic Over 5 Years in Chronic Heart Failure

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Laszczynska, O (Autor) Outra; Severo M (Autor) FMUP; Friões F (Autor) FMUP; Lourenco, P (Autor) FMUP; Silva, S (Autor) Outra; Bettencourt P (Autor) FMUP; Lunet N (Autor) FMUP; Azevedo A (Autor) FMUP

Revista

Título: Journal of Cardiac Failure

Vol. 23

Páginas: 589-593

ISSN: 1071-9164

Editora: Elsevier

Indexação

ISI Web of Knowledge - 8 Citações

Scopus - 9 Citações

Outras Informações

ID Authenticus: P-00M-YZ7

DOI: 10.1016/j.cardfail.2017.04.001

Abstract (EN): Background: High diuretic doses in chronic heart failure (HF) are potentially deleterious. We assessed the effect of dynamic furosemide dose on all-cause mortality among HF ambulatory patients. Methods and Results: A cohort of 560 ambulatory patients from an outpatient clinic specialized in HF, with median age 70 years, 67% male, and 89% with moderate-severely reduced ejection fraction, was retrospectively followed for up to 5 years. Dynamic furosamide exposure was categorized as low (0-59 mg/d), medium (60-119 mg/d), high (120-159 mg/d), and very high (>= 160 mg/d). Extended Cox models were used to estimate the association between time-varying diuretic dose and mortality. A dose-dependent crude association between higher doses of furosemide and death (hazard ratio [HR] = 1.34, 95% confidence interval (CI): 1.06-2.16; HR = 2.09, 95% CI: 1.54-2.84, for high and very high dose, respectively) was totally explained by patients' characteristics and disease severity indicators (adjusted HR = 0.94, 95% CI: 0.63-1.38; HR = 1.10, 95% CI: 0.79-1.55, for high and very high dose, respectively). Conclusion: In this context, higher doses of diuretic did not impair survival, but rather indicated greater severity of the patient's condition.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5