Exercise as a therapeutic tool to prevent mitochondrial degeneration in nonalcoholic steatohepatitis

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2013

Autores

goncalves, io (Autor) Outra; oliveira, pj (Autor) Outra; ascensao, a (Autor) FADEUP; magalhaes, j (Autor) FADEUP

Revista

Título: European Journal of Clinical Investigation

Vol. 43

Páginas: 1184-1194

ISSN: 0014-2972

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 18 Citações

Scopus - 19 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-006-6C8

DOI: 10.1111/eci.12146

Abstract (EN): Nonalcoholic fatty liver disease, encompassing hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis, is a significant health problem associated with modern lifestyle, based on caloric overconsumption and physical inactivity. Although the mechanisms associated with progression from the benign' steatosis to NASH are still elusive, mitochondrial dysfunction seems to play an important role in this degenerative process. Degeneration of mitochondrial function during NASH has been associated with impaired -oxidation, oxidative phosphorylation and increased reactive oxygen species production, contributing to hepatocyte death and inflammatory response. Despite the fact that several therapeutic approaches can be used in the context of NASH, including insulin-sensitizing agents, anti-obesity drugs, lipid-lowering drugs or mitochondrial-targeted drugs, dietary and physical activity are still the most effective strategies. In fact, active lifestyles decrease insulin resistance and body weight and result in decreased histological signs of liver injury. In fatty liver, physical activity prevents the disease progression through mitochondrial adaptations, namely by increasing cytochrome c content, enzyme activities and fatty acid oxidation, which are lost after some days of physical inactivity. However, less is known about the effect of physical activity on NASH-associated mitochondrial dysfunction. After a brief characterization of NASH and its association with liver mitochondrial (dys)function, the present review addresses the impact of physical (in)activity on NASH and, particularly, the possible contribution of active lifestyles to the modulation of liver mitochondrial dysfunction.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11