Hematological remission and long term hematological control of acute myeloblastic leukemia induced and maintained by granulocyte-colony stimulating factor (G-CSF) therapy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2003

Autores

Xavier, L (Autor) Outra; Cunha, M (Autor) Outra; Goncalves, C (Autor) Outra; Teixeira, MD (Autor) Outra; Coutinho, J (Autor) Outra; Ribeiro, ACP (Autor) Outra; Lima, M (Autor) Outra

Revista

Título: LEUKEMIA & LYMPHOMA

Vol. 44

Páginas: 2137-2142

ISSN: 1042-8194

Editora: INFORMA HEALTHCARE

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 5 Citações

Outras Informações

ID Authenticus: P-000-EB2

DOI: 10.1080/1042819031000111053

Abstract (EN): We describe a case of a patient with CD34+, TdT+, CD13-, CD33-, MPO- undifferentiated acute leukemia who refused chemotherapy and who achieved complete hematological remission 14 months after the diagnosis, during a short course of granulocyte-colony stimulating factor (G-CSF) for neutropenia and life threatening infection. Relapse occurred approximately one year later and G-CSF was reintroduced, being maintained for 4 months, at a dose and frequency adapted to maintain normal blood counts, a complete hematological remission being achieved again. Five months after withdrawing the G-CSF therapy a second relapse was observed; G-CSF was tried again with success, resulting in a very good hematological response that was sustained by G-CSF maintenance therapy. One year latter there was the need of increasing the doses of G-CSF in order to obtain the same hematological effect, at same time blast cells acquired a more mature CD34+, TdT-, CD13+, CD33-, MPO+ myeloid phenotype. Finally, the patient developed progressive neutropenia, anemia, thrombocytopenia and acute leukemia in spite of G-CSF therapy, dying 64 months after initial diagnosis (50 months after starting G-CSF therapy) with overt G-CSF resistant acute myeloblastic leukemia (AML), after failure of conventional induction chemotherapy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6