Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2018

Autores

Fernandes, AR (Autor) Outra; Santos, AC (Autor) Outra; Sanchez Lopez, E (Autor) Outra; Kovacevic, AB (Autor) Outra; Espina, M (Autor) Outra; Calpena, AC (Autor) Outra; Veiga, FJ (Autor) Outra; Garcia, ML (Autor) Outra; Souto, EB (Autor) Outra

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: SKIN PHARMACOLOGY AND PHYSIOLOGY

Vol. 31

Páginas: 59-73

ISSN: 1660-5527

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 11 Citações

Outras Informações

ID Authenticus: P-00N-RGS

DOI: 10.1159/000479529

Abstract (EN): Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most common malignant tumors in humans. BCCs do not proliferate rapidly and most of the times do not metastasize, while SCCs are more infiltrative, metastatic, and destructive. AKs are precursor lesions of cutaneous SCCs. The classical therapy of NMSCs makes use of photodynamic therapy associated with chemotherapeutics. With improved understanding of the pathological mechanisms of tumor initiation, progression, and differentiation, a case is made towards the use of targeted chemotherapy with the intent to reduce the cytotoxicity of classical treatments. The present review aims to describe the current state of the art on the knowledge of NMSC, including its risks factors, oncogenes, and skin carcinogenesis, discussing the classical therapy against new therapeutic options. (C) 2017 S. Karger AG, Basel

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15