Aspirin and blood pressure: Effects when used alone or in combination with antihypertensive drugs

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2017

Autores

Costa, AC (Autor) Outra; Marta R Couto (Autor) FMUP; Albino Teixeira, A (Autor) FMUP; Sousa, T (Autor) FMUP

Revista

Título: Revista Portuguesa de Cardiologia

Vol. 36

Páginas: 551-567

ISSN: 0870-2551

Editora: Sociedade Portuguesa De Cardiologia

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 14 Citações

Outras Informações

ID Authenticus: P-00R-ASN

DOI: 10.1016/j.repc.2017.05.008

Abstract (EN): Arterial hypertension is a major risk factor for cardiovascular and renal events. Lowering blood pressure is thus an important strategy for reducing morbidity and mortality. Since low-dose aspirin is a cornerstone in the prevention of adverse cardiovascular outcomes, combined treatment with aspirin and antihypertensive drugs is very common. However, the impact of aspirin therapy on blood pressure control remains a subject of intense debate. Recent data suggest that the cardioprotective action of aspirin extends beyond its well-known antithrombotic effect. Aspirin has been shown to trigger the synthesis of specialized pro-resolving lipid mediators from arachidonic acid and omega-3 fatty acids. These novel anti-inflammatory and pro-resolving mediators actively stimulate the resolution of inflammation and tissue regeneration. Additionally, they may contribute to other protective effects on redox status and vascular reactivity that have also been attributed to aspirin. Of note, aspirin has been shown to improve vasodilation through cyclooxygenase-independent mechanisms. On the other hand, higher aspirin doses have been reported to exert a negative impact on blood pressure due to inhibition of cyclooxygenase-2 activity, which reduces renal blood flow, glomerular filtration rate and sodium and water excretion. This review aims to provide an overview of the effects of aspirin on blood pressure and the underlying mechanisms, focusing on the interaction between aspirin and antihypertensive drugs. Studies in both experimental and human hypertension are presented.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 17